权威例句
Effects of an Rb mutation in the mouseRb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular SenescenceMice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomasCooperative tumorigenic effects of germline mutations in Rb and p53.The E2F transcription factor is a cellular target for the RB proteinTargeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalizationEvidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathwaysDahlof B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, et al., LIFE Study Group. Cardiovascular morbidity and mortalit...