scrapie

n.

（羊患的）痒病；

1. Genetic treatment shows promise against scrapie.
   基因疗法对于对抗羊瘙痒病是有希望的。

Self-replication and scrapie.
Scrapie prions aggregate to form amyloid-like birefringent rods.
Scrapie prion protein contains a phosphatidylinositol glycolipid
A cellular gene encodes scrapie PrP 27-30 protein.
Mice devoid of PrP are resistant to scrapie.
Identification of a Protein that Purifies with the Scrapie Prion
A protease-resistant protein is a structural component of the Scrapie prion
Büeler, H.R. et al. Mice devoid of PrP are resistant to scrapie. Cell 73, 1339-1347
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?