权威例句
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma ...
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Differential sensitivity of melanoma cell lines with BRAF V600E mutation to the specific Raf inhibitor PLX4032
BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involv...