presenilin

释义

[医]早老素；

Protein Topology of Presenilin 1
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
Familial Alzheimer's disease-linked presenilin I variants elevate aβ1- 42/1-40 ratio in vitro and in vivo
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
Duff, K. et al. Increased amyloid-42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.
Wolfe, M.S. etal. Two transmembrane aspartates in presenilin-1 required presenilin endoproteolysis and -sectretasse activity. Nature...
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 ...