Birbeck granules

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Birbeck granules

Birbeck granules, also known as Birbeck bodies, are rod shaped or "tennis-racket"cytoplasmic organelles with a central linear density and a striated appearance. They are a characteristic microscopic finding in Langerhans cell histiocytosis (Histiocytosis X), which is one of a group of rare conditions collectively known as histiocytosis.

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Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin ac...
Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.
Delineation of the dendritic cell lineage by generating large numbers of Birbeck granule-positive Langerhans cells from human periph...
McDermott R, Ziylan U, Spehner D, Bausinger H, Lipsker D, Mommaas M et al.Birbeck granules are subdomains of endosomal recycling com...
In vitro differentiation of CD34+ hematopoietic progenitor cells toward distinct dendritic cell subsets of the birbeck granule and M...
Cytomembrane-derived Birbeck granules transport horseradish peroxidase to the endosomal compartment in the human Langerhans cells.
Direct evidence for the cytomembrane derivation of Birbeck granules: the membrane-sandwich effect.
Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells
Birbeck Granules (Langerhans’ Cell Granules) in Human Lymph Nodes
A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene